A Short Review on the Safety of Bromphenol Blue for Dye-Assisted Vitreoretinal Interventions.

Abstract

Bromphenol blue was approved for the intraoperative staining of the vitreous, epiretinal membranes, and internal limiting membrane of the retina several years ago. It has been marketed as a combined dye formulation of bromphenol blue (1.3 mg/mL) and brilliant blue G (0.25 mg/mL). So far, comprehensive information on preclinical and clinical safety data of bromphenol blue is lacking. A PubMed analysis of available literature was performed. Ten relevant publications on preclinical and clinical evaluations of bromphenol blue were found. It is striking that almost no safety data is available on the presently used clinical product. Current clinical use seems not completely be justified by scientific safety data.

• Authors: Heinrich Gerding
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 237 Issue 4 Pg. 441-445 (Apr 2020) ISSN: 1439-3999 [Electronic] Germany
• Vernacular Title: Eine kurze Übersicht zur Sicherheit von Bromphenolblau bei farbstoffassistierten vitreoretinalen Interventionen.
• PMID: 32018279 (Publication Type: Journal Article, Review)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Coloring Agents
• Rosaniline Dyes
• Bromphenol Blue

Topics

• Bromphenol Blue
• Coloring Agents
• Epiretinal Membrane (surgery)
• Humans
• Rosaniline Dyes
• Staining and Labeling
• Vitrectomy