Stem Cell Therapy in Brain Ischemia: The Role of Mitochondrial Transfer.

Abstract

Mitochondrial dysfunction is an important pathological process in the setting of ischemic brain injury. Stem cell-mediated mitochondrial transfer provides an efficient intercellular process to supply additional mitochondria in the ischemic brain tissues. In this review, we summarize the mitochondrial pathology associated with brain ischemia, mechanisms of stem cell-mediated mitochondrial transfer, and in vitro/in vivo experimental findings of mitochondrial transfer from stem cells to ischemic vascular endothelial cells/neurons as potential therapeutic strategy in the management of ischemic brain injury.

• Authors: Lei Huang, Cesar Reis, Warren W Boling, John H Zhang
• Journal: Stem cells and development (Stem Cells Dev) Vol. 29 Issue 9 Pg. 555-561 (05 01 2020) ISSN: 1557-8534 [Electronic] United States
• PMID: 31964239 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Animals
• Brain Ischemia (therapy)
• Cell- and Tissue-Based Therapy (methods)
• Endothelial Cells (cytology)
• Humans
• Mitochondria (physiology)
• Neurons (cytology)
• Stem Cells (cytology)