Late-onset myasthenia gravis successfully treated with local resection of cervical ectopic thymoma.

Abstract

A 78-year-old woman was admitted complaining progressive respiratory failure, neck weakness and gait disturbance. She was diagnosed as acetylcholine receptor antibody-positive myasthenia gravis crisis with ectopic cervical thymoma. After she recovered from crisis by plasmapheresis and administration of prednisone, we did not choose extended thymectomy but chose local resection of ectopic thymoma considering her age and complications. After the operation, she got minimal manifestations and no relapse of thymoma. Although international and Japanese guidelines recommend extended thymectomy for myasthenia gravis with thymoma, isolated local resection of ectopic thymoma may be enough for controlling myasthenia gravis especially in elderly patients.

• Authors: Teruhiko Sekiguchi, Ken Yoshida, Yukina Minamihara, Hiroki Hayashi, Teruaki Oka, Satoshi Orimo
• Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 73 Pg. 321-323 (Mar 2020) ISSN: 1532-2653 [Electronic] Scotland
• PMID: 31926660 (Publication Type: Case Reports)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Topics

• Aged
• Female
• Humans
• Myasthenia Gravis (complications, surgery, therapy)
• Plasmapheresis
• Thymectomy (adverse effects)
• Thymoma (complications, surgery)
• Thymus Neoplasms (complications, surgery)