Evaluation of the association between KIR polymorphisms and systemic sclerosis: a meta-analysis.

Abstract

BACKGROUND:

The results of investigations on the association between killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and the risk of systemic sclerosis (SSc) are inconsistent. To comprehensively evaluate the influence of KIR polymorphisms on the risk of SSc, this meta-analysis was performed.

METHODS:

A systematic literature search was performed in electronic databases including Scopus and PubMed/MEDLINE to find all available studies involving KIR gene family polymorphisms and SSc risk prior to July 2019. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were measured to detect associations between KIR gene family polymorphisms and SSc risk.

RESULTS:

Five articles, comprising 571 patients and 796 healthy participants, evaluating the KIR gene family polymorphisms were included in the final meta-analysis according to the inclusion and exclusion criteria, and 16 KIR genes were assessed. None of the KIR genes were significantly associated with the risk of SSc.

CONCLUSIONS:

The current meta-analysis provides evidence that KIR genes might not be potential risk factors for SSc risk.

• Authors: Elham Karimizadeh, Shayan Mostafaei, Saeed Aslani, Farhad Gharibdoost, Ricardo Machado Xavier, Patricia Hartstein Salim, Hoda Kavosi, Elham Farhadi, Mahdi Mahmoudi
• Journal: Advances in rheumatology (London, England) (Adv Rheumatol) Vol. 60 Issue 1 Pg. 8 (01 10 2020) ISSN: 2523-3106 [Electronic] England
• PMID: 31924272 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)

Chemical References

• Receptors, KIR

Topics

• Confidence Intervals
• Humans
• Odds Ratio
• Polymorphism, Genetic
• Publication Bias
• Receptors, KIR (genetics)
• Risk
• Scleroderma, Systemic (genetics)