Abstract | BACKGROUND: OBJECTIVE: To investigate the correlations between serum vitamin D levels and risk and prognosis of melanoma. METHODS: A systematic review and meta-analysis were conducted. Online databases were searched on 31 Oct 2018. RESULTS: Twenty-five studies with a total of 11166 patients with melanoma were included. There was no significant difference in serum vitamin D levels between patients with melanoma and controls [standardized mean difference (SMD), -0.185; 95% confidence interval (CI), -0.533 to 0.162]. However, the prevalence of vitamin D deficiency was significantly higher in patients with melanoma than that in controls (odds ratio, 2.115; 95% CI, 1.151-3.885). In terms of prognosis, serum vitamin D levels were significantly higher in melanoma patients with lower Breslow thickness (≦1 vs. >1 mm: SMD, 0.243; 95% CI, 0.160-0.327). Moreover, melanoma patients with lower vitamin D levels had a significantly higher mortality rate (hazard ratio, 1.558; 95% CI, 1.258-1.931). CONCLUSIONS:
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Authors | T-Y Tsai, C-Y Kuo, Y-C Huang |
Journal | Journal of the European Academy of Dermatology and Venereology : JEADV
(J Eur Acad Dermatol Venereol)
Vol. 34
Issue 8
Pg. 1722-1729
(Aug 2020)
ISSN: 1468-3083 [Electronic] England |
PMID | 31919907
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | © 2020 European Academy of Dermatology and Venereology. |
Chemical References |
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Topics |
- Humans
- Melanoma
(epidemiology)
- Prognosis
- Ultraviolet Rays
- Vitamin D
- Vitamin D Deficiency
(complications, epidemiology)
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