Abstract | BACKGROUND: METHODS: RESULTS: Initially, enrollment of 21 patients was planned; however, the trial was prematurely closed due to slow recruitment. Finally, a total of 8 patients were enrolled between January 2012 and July 2015 from one institute. All patients completed concurrent chemoradiotherapy, and 6 patients (75.0%) received consolidation chemoradiotherapy. The ORR was 75%, with complete response (CR) 1 (12.5%), partial remission 6 (62.5%), stable disease 1 (12.5%), progressive disease 1 (12.5%), respectively. After a median follow-up of 15.2 (range, 2.3-51.5) months, 7 patients were dead, and 1 was alive. The median PFS and OS were 12.1 and 15.2 months, respectively. According to Common Terminology Criteria for Adverse Events version 4.0, 6 patients (75.0%) experienced acute radiation esophagitis, 4 (50.0%) were grade 2 (G2), and 2 (25.0%) were G3; 4 patients (50%) experienced acute radiation pneumonitis, 3 (37.5%) were G2, and 1 (12.5%) was G3. No late radiation-induced esophageal and pulmonary toxicity was observed after 1-year follow-up. CONCLUSIONS:
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Authors | Kan Wu, Lucheng Zhu, Jiahao Wang, Kaicheng Pan, Bing Wang, Xin Li, Shaoyu Yang, Xiao Xu, Minna Zhang, Xiadong Li, Xueqin Chen, Shenglin Ma, Bing Xia |
Journal | Journal of thoracic disease
(J Thorac Dis)
Vol. 11
Issue 11
Pg. 4529-4537
(Nov 2019)
ISSN: 2072-1439 [Print] China |
PMID | 31903241
(Publication Type: Journal Article)
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Copyright | 2019 Journal of Thoracic Disease. All rights reserved. |