Comparative Study of Microbiological Profile and Management Outcomes of Acute Endophthalmitis after Microincision Vitrectomy Surgery versus Intravitreal Injections.

Abstract	Purpose: The aim of this study was to evaluate and compare incidence and outcomes of management of acute endophthalmitis after microincision vitrectomy surgery (MIVS) and intravitreal injections (IVIs).Methods: Medical records were retrospectively reviewed from January 2012 to December 2017, and the incidence, clinical and microbiological profiles of acute endophthalmitis were documented.Results: Of 26,332 MIVS and 24,143 IVI performed, incidence of acute endophthalmitis in MIVS group was 0.027% (1 in 3761 cases) against 0.054% (1 in 1857 cases) in IVI. Gram-positive organisms were causative in post IVI group as against gram-negative organisms in MIVS group.Conclusion: Incidence of endophthalmitis after IVI is almost twice that after MIVS. A trend toward poorer outcomes in MIVS eyes was observed. Both MIVS and IVI being pars plana procedures warrant similar kind of aseptic precautions.
Authors	Naresh Babu Kannan, Sagnik Sen, Chitaranjan Mishra, Prajna Lalitha, Gunasekaran Rameshkumar, Renu P Rajan, Karthik Kumar Arumugam, Kim Ramasamy
Journal	Ocular immunology and inflammation (Ocul Immunol Inflamm) Vol. 29 Issue 5 Pg. 838-844 (Jul 04 2021) ISSN: 1744-5078 [Electronic] England
PMID	31900009 (Publication Type: Comparative Study, Journal Article)
Chemical References	Angiogenesis Inhibitors Anti-Bacterial Agents Glucocorticoids VEGFA protein, human Vascular Endothelial Growth Factor A Bevacizumab Ranibizumab
Topics	Acute Disease Adult Aged Angiogenesis Inhibitors (administration & dosage) Anti-Bacterial Agents (therapeutic use) Aqueous Humor (microbiology) Bevacizumab (administration & dosage) Drug Therapy, Combination Endophthalmitis (diagnosis, drug therapy, epidemiology, microbiology) Eye Infections, Bacterial (diagnosis, drug therapy, epidemiology, microbiology) Female Glucocorticoids (therapeutic use) Gram-Negative Bacteria (isolation & purification) Gram-Positive Bacteria (isolation & purification) Humans Incidence Intravitreal Injections (adverse effects) Male Microsurgery Middle Aged Ranibizumab (administration & dosage) Retrospective Studies Treatment Outcome Vascular Endothelial Growth Factor A (antagonists & inhibitors) Visual Acuity (physiology) Vitrectomy (adverse effects) Vitreous Body (microbiology)

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