Pd@Au Bimetallic Nanoplates Decorated Mesoporous MnO2 for Synergistic Nucleus-Targeted NIR-II Photothermal and Hypoxia-Relieved Photodynamic Therapy.

Abstract

Bimetallic nanoparticles have received considerable attention owing to synergistic effect and their multifunctionality. Herein, new multifunctional Pd@Au bimetallic nanoplates decorated hollow mesoporous MnO2 nanoplates (H-MnO2 ) are demonstrated for achieving not only nucleus-targeted NIR-II photothermal therapy (PTT), but also tumor microenvironment (TME) hypoxia relief enhanced photodynamic therapy (PDT). The Pd@Au nanoplates present a photothermal conversion efficiency (PTCE) as high as 56.9%, superior to those PTAs activated in the NIR-II region such as Cu9 S5 nanoparticles (37%), Cu3 BiS3 nanorods (40.7%), and Au/Cu2-x S nanocrystals (43.2%). They further functionalize with transactivator of transcription (TAT) moiety for cell nuclear-targeting and biodegradable hollow mesoporous MnO2 (≈100 nm) loaded with photosensitizer Ce6 (TAT-Pd@Au/Ce6/PAH/H-MnO2 ) to construct a hierarchical targeting nanoplatform. The as-made TAT-Pd@Au/Ce6/PAH/H-MnO2 demonstrates good premature renal clearance escape ability and increased tumor tissue accumulation. It can be degraded in acidic TME and generate O2 by reacting to endogenous H2 O2 to relieve the hypoxia for enhanced PDT, while the released small TAT-Pd@Au nanoplates can effectively enter into the nucleus to mediate PTT. As a result, a remarkable therapeutic effect is achieved owing to the synergistic PTT/PDT therapy. This hierarchical targeting, TME-responsive, cytoplasm hypoxia relief PDT, and nuclear NIR-II PTT synergistic therapy can pave a new avenue for nanomaterials-based cancer therapy.

• Authors: Yiyi Zhang, Fan Lv, Yaru Cheng, Zhipeng Yuan, Fan Yang, Conghui Liu, Yu Cao, Kai Zhang, Huiting Lu, Shah Zada, Shaojun Guo, Haifeng Dong, Xueji Zhang
• Journal: Advanced healthcare materials (Adv Healthc Mater) Vol. 9 Issue 2 Pg. e1901528 (01 2020) ISSN: 2192-2659 [Electronic] Germany
• PMID: 31820854 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antineoplastic Agents
• Manganese Compounds
• Oxides
• Photosensitizing Agents
• Palladium
• Gold
• Hydrogen Peroxide
• Oxygen
• manganese dioxide

Topics

• Animals
• Antineoplastic Agents (administration & dosage, chemistry, pharmacology)
• Female
• Gold (chemistry)
• Humans
• Hydrogen Peroxide (chemistry)
• MCF-7 Cells
• Manganese Compounds (chemistry)
• Metal Nanoparticles (chemistry)
• Mice, Inbred BALB C
• Multifunctional Nanoparticles
• Oxides (chemistry)
• Oxygen (pharmacokinetics)
• Palladium (chemistry)
• Photochemotherapy (methods)
• Photosensitizing Agents (chemistry, pharmacology)
• Photothermal Therapy (methods)
• Theranostic Nanomedicine (methods)
• Tumor Hypoxia (drug effects)
• Tumor Microenvironment
• Xenograft Model Antitumor Assays