Efficacy of single topical treatment of Selamectin (Revolution®) against Ancylostoma ceylanicum in experimentally infected cats.

Abstract

Ancylostoma ceylanicum, a species of hookworm, is a common parasite of dogs and cats in the Asia-Pacific region. The objective of this study was to determine the efficacy of a single topical treatment of selamectin (Revolution®) against A. ceylanicum in experimentally infected cats. 12 kittens were injected with 300 infective stage larvae (L3) of A. ceylanicum by the subcutaneous route. Faecal samples were examined daily (days 7-15) for the presence of hookworm eggs. On day 18 kittens were stratified by faecal egg count and randomly allocated in equal numbers to control (n = 6) and treatment (n = 6) groups. Faecal egg counts were then performed daily (days 14-27) or every 3 days (days 28-51) until the end of the study and compared between the treated and control groups. Kittens in the treatment group were administered a single topical dose of selamectin (Revolution®), per label recommendations (6 mg/kg), on day 19. Kittens in the control group were not treated. At 4 days post-treatment, no hookworm eggs were detected in the treated group. Faecal samples from this group remained negative throughout the study, the treatment efficacy was 100% egg reduction (P < .0001). Average faecal egg counts remained high (558 ± 231 eggs per gram) in the untreated control group until the end of the study period. In conclusion, a single topical treatment of selamectin (Revolution®) at the recommended dose was highly efficacious against infection with A. ceylanicum in cats.

• Authors: Piyanan Taweethavonsawat, Thitirat Chaimee, Patcharin Priyavoravong, Rebecca J Traub
• Journal: Veterinary parasitology, regional studies and reports (Vet Parasitol Reg Stud Reports) Vol. 18 Pg. 100346 (12 2019) ISSN: 2405-9390 [Electronic] Netherlands
• PMID: 31796176 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Antinematodal Agents
• Ivermectin
• selamectin

Topics

• Administration, Topical
• Ancylostoma (drug effects)
• Ancylostomiasis (drug therapy, veterinary)
• Animals
• Antinematodal Agents (therapeutic use)
• Cat Diseases (drug therapy)
• Cats
• Ivermectin (analogs & derivatives, therapeutic use)