Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Abstract

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.

• Authors: Rong Tian, Wilson S. Colucci, Zoltan Arany, Markus M. Bachschmid, Scott W. Ballinger, Sihem Boudina, James E. Bruce, David W. Busija, Sergey Dikalov, Gerald W. Dorn II, Zorina S. Galis, Roberta A. Gottlieb, Daniel P. Kelly, Richard N. Kitsis, Mark J. Kohr, Daniel Levy, E. Douglas Lewandowski, Joseph M. McClung, Daria Mochly-Rosen, Kevin D. O'Brien, Brian O'Rourke, Joon-Young Park, Peipei Ping, Michael N. Sack, Shey-Shing Sheu, Yang Shi, Sruti Shiva, Douglas C. Wallace, Robert G. Weiss, Hilary J. Vernon, Renee Wong, Lisa Schwartz Longacre
• Journal: Circulation (Circulation) Vol. 140 Issue 14 Pg. 1205-1216 (10 01 2019) ISSN: 1524-4539 [Electronic] United States
• PMID: 31769940 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2019 American Heart Association, Inc.

Topics

• Biomedical Research (methods, trends)
• Cardiovascular System (pathology)
• Education (methods, trends)
• Heart Failure (diagnosis, epidemiology, therapy)
• Humans
• Mitochondria (physiology)
• National Heart, Lung, and Blood Institute (U.S.) (trends)
• Research Report (trends)
• Translational Research, Biomedical (methods, trends)
• United States (epidemiology)