Prognostic indicators in pancreatic cancer patients undergoing total pancreatectomy.

Abstract

PURPOSE:

To evaluate the long-term outcomes of total pancreatectomy in a modern cohort of pancreatic cancer patients and to establish whether any factors identified prior to pancreatic resection were related to poor survival.

METHODS:

We analyzed, retrospectively, patients who underwent total pancreatectomy for pancreatic cancer between 2007 and 2016. The short- and long-term outcomes were investigated and Cox regression analysis was used to evaluate the prognostic factors identified before resection.

RESULTS:

The subjects were 49 patients with a mean age of 65 years, who underwent total pancreatectomy in our hospital during the study period. Peritoneal washing cytology was performed in 48 patients, with positive results in 4 (8.3%). There was no 30-day mortality. The median overall survival was 22.5 months, with a 5-year survival rate of 28.5%. Univariate analyses of the pre-resection variables revealed that overall survival was associated with tumor location, resectability classification, maximum standardized uptake value of positron emission tomography, the preoperative carbohydrate antigen 19-9 level, and peritoneal washing cytology status. Multivariate analysis revealed that positive peritoneal washing cytology status and the maximum standardized uptake value were independent predictors of poor survival.

CONCLUSION:

Total pancreatectomy for pancreatic cancer is appropriate for selected patients, but peritoneal washing cytology and positron emission tomography should be performed preoperatively.

• Authors: Shimpei Maeda, Kyohei Ariake, Masahiro Iseki, Hideo Ohtsuka, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Hiroki Hayashi, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
• Journal: Surgery today (Surg Today) Vol. 50 Issue 5 Pg. 490-498 (May 2020) ISSN: 1436-2813 [Electronic] Japan
• PMID: 31768656 (Publication Type: Journal Article)

Chemical References

• CA-19-9 Antigen

Topics

• Aged
• CA-19-9 Antigen
• Cytodiagnosis (methods)
• Female
• Humans
• Male
• Pancreatectomy (methods)
• Pancreatic Neoplasms (mortality, pathology, surgery)
• Peritoneum (cytology, pathology)
• Prognosis
• Proportional Hazards Models
• Retrospective Studies
• Survival Rate