131 I-Labeled Multifunctional Polyphosphazene Nanospheres for SPECT Imaging-Guided Radiotherapy of Tumors.

Abstract

Design of theranostic nanoplatforms represents a major topic for current nanomedicine. Here, the preparation of multifunctional poly(cyclotriphosphazene-co-polyethylenimine) nanospheres (PNSs) labeled with radionuclide 131 I for single photon emission computed tomography (SPECT) imaging-guided radiotherapy of tumors is reported. In this work, PNSs are prepared using hexachlorocyclotriphosphazene as a crosslinker to crosslink branched polyethylenimine (PEI) via a nucleophilic substitution reaction, modified with 3-(4'-hydroxyphenyl) propionic acid-OSu (HPAO) for 131 I labeling, and reacted with 1,3-propane sulfonate (1,3-PS) to render the particles with antifouling property, followed by acetylation of the remaining surface amines and labeling with 131 I. The acquired PNS.NHAc-HPAO(131 I)-PS particles are well characterized. It is shown that the multifunctional PNSs with an average size of 184 ± 29.3 nm exhibit favorable antifouling properties, high 131 I labeling efficiency (76.05 ± 3.75%), and excellent radiostability and colloidal stability. With these properties owned, the developed PNS.NHAc-HPAO(131 I)-PS spheres enable much more efficient SPECT imaging and radiotherapy of a xenografted tumor model in vivo than the PEI counterpart material (PEI.NHAc-HPAO(131 I)-PS). The developed PNSs may be used as a versatile platform for further development of different forms of nanomedicine for various biomedical applications.

• Authors: Wei Zhu, Lingzhou Zhao, Yu Fan, Jinhua Zhao, Xiangyang Shi, Mingwu Shen
• Journal: Advanced healthcare materials (Adv Healthc Mater) Vol. 8 Issue 23 Pg. e1901299 (12 2019) ISSN: 2192-2659 [Electronic] Germany
• PMID: 31697048 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Organophosphorus Compounds
• Polymers
• poly(phosphazene)
• Polyethyleneimine

Topics

• Animals
• Cell Line, Tumor
• Cell Survival (physiology)
• Humans
• Mice
• Nanospheres (chemistry)
• Organophosphorus Compounds (chemistry)
• Polyethyleneimine (chemistry)
• Polymers (chemistry)
• Spectroscopy, Fourier Transform Infrared
• Tomography, Emission-Computed, Single-Photon (methods)