Retinal nerve fibre changes in sports-related repetitive traumatic brain injury.

Abstract

IMPORTANCE:

There is limited literature on the use of optical coherence tomography in the assessment of retinal nerve fibre layer (RNFL) thickness in sports-related repetitive mild traumatic brain injury.

BACKGROUND:

To evaluate RNFL thickness in professional rugby league players. RNFL thinning may serve as a proxy for wider white matter degeneration.

DESIGN:

Cross-sectional observational study.

PARTICIPANTS:

Thirteen retired Australian professional rugby league players were recruited.

METHODS:

Participants underwent binocular optical coherence tomography to measure RNFL thickness. Each participant underwent a complete ophthalmic assessment to exclude concurrent disease.

MAIN OUTCOME MEASURES:

RNFL thickness of each eye were compared with a normative database.

RESULTS:

Participants had played professional Rugby League for 18 years on average and reported sustaining 15 sports-related concussions throughout their career. The RNFL in participants was four micrometres thinner than that of matched normative data. Cohort average RNFL thickness was reduced in 12 out of 14 optical coherence testing parameters. These findings were statistically significant in the left inferonasal [P = .013] and left nasal [P = .006] sectors. There was no statistically significant relationship between RNFL thickness and other visual measures.

CONCLUSIONS AND RELEVANCE:

This study is the first to demonstrate RNFL thinning in a cohort of retired Australian professional Rugby League players. RNFL changes have been shown to correlate with cerebral white matter loss and neurodegeneration. Optical coherence tomography may serve as a safe and economical means of screening for repetitive traumatic brain injury related neurodegeneration in contact sport athletes.

• Authors: Julian C Kelman, Christopher Hodge, Peter Stanwell, Nina Mustafic, Clare L Fraser
• Journal: Clinical & experimental ophthalmology (Clin Exp Ophthalmol) Vol. 48 Issue 2 Pg. 204-211 (03 2020) ISSN: 1442-9071 [Electronic] Australia
• PMID: 31691473 (Publication Type: Journal Article, Observational Study)
• Copyright: © 2019 Royal Australian and New Zealand College of Ophthalmologists.

Topics

• Adult
• Aged
• Humans
• Male
• Middle Aged
• Brain Injuries, Traumatic (diagnostic imaging, physiopathology)
• Cross-Sectional Studies
• Football (injuries)
• Nerve Fibers (pathology)
• Refraction, Ocular (physiology)
• Retinal Ganglion Cells (pathology)
• Tomography, Optical Coherence
• Vision Disorders (physiopathology)
• Visual Acuity (physiology)