Antihistamines and Ovarian Cancer Survival: Nationwide Cohort Study and in Vitro Cell Viability Assay.

Abstract

Antihistamines with cationic amphiphilic drug (CAD) characteristics induce cancer-specific cell death in experimental studies. Epidemiologic evidence is, however, limited. In a Danish nationwide cohort of ovarian cancer patients diagnosed during 2000-2015 (n = 5075), we evaluated the association between filled antihistamine prescriptions and cancer mortality. We used Cox regression models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for ovarian cancer mortality. In an in vitro cell viability assay, we evaluated cell death in three ovarian cancer cell lines after treatment with clinically relevant doses of eight antihistamines. In our cohort study, CAD antihistamine use (≥1 prescription; n = 133) was associated with a hazard ratio of 0.63 (95% CI = 0.40 to 0.99) compared to use of non-CAD antihistamines (n = 304), and we found a tendency toward a dose-response association. In our cell viability assay, we found consistent and dose-dependent cytotoxicity for all CAD but not non-CAD antihistamines. In this nationwide cohort study, use of antihistamines with CAD characteristics is associated with a prognostic benefit in ovarian cancer patients.

• Authors: Freija Verdoodt, Christian Dehlendorff, Marja Jäättelä, Robert Strauss, Anton Pottegård, Jesper Hallas, Søren Friis, Susanne K Kjaer
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 112 Issue 9 Pg. 964-967 (09 01 2020) ISSN: 1460-2105 [Electronic] United States
• PMID: 31688928 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected].

Chemical References

• Cations
• Histamine Antagonists
• Surface-Active Agents

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Ovarian Epithelial (complications, mortality, pathology)
• Cations
• Cell Line, Tumor
• Cell Survival (drug effects)
• Cohort Studies
• Denmark (epidemiology)
• Drug Screening Assays, Antitumor
• Female
• Histamine Antagonists (pharmacology, therapeutic use)
• Humans
• Middle Aged
• Mortality
• Ovarian Neoplasms (complications, mortality, pathology)
• Surface-Active Agents (pharmacology, therapeutic use)