Abstract |
The treatment of pulmonary infections with antibiotics administered via pulmonary delivery provides for higher local therapeutic efficacy rather than through systemic administration. Pneumonia is globally considered a major cause of death due to a lack of proper medication. The treatment of pneumonia with inhalable antibiotics (such as azithromycin (AZM)) can provide a maximum pulmonary therapeutic effect without significant systemic side effects. Compared to non-effervescent microparticles, effervescent microparticles can provide an active driving force to release loaded antibiotics for subsequent distribution deep into the lung by virtue of its smaller size. In this study, N-fumaroylated diketopiperazine ( FDKP) was used as a carrier to prepare effervescent inhalable microparticles loaded with AZM (AZM@ FDKP-E-MPs). This effervescent dry powder was characterized for both in vitro and in vivo deposition in the lung and the results obtained showed significant improvement in lung deposition and anti-bacterial efficiency, suggesting a strong potential application for pneumonia treatment.
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Authors | Qiyue Wang, Yan Shen, Gujie Mi, Dongsheng He, Yue Zhang, Yerong Xiong, Thomas J Webster, Jiasheng Tu |
Journal | Biomaterials
(Biomaterials)
Vol. 228
Pg. 119575
(01 2020)
ISSN: 1878-5905 [Electronic] Netherlands |
PMID | 31677394
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019. Published by Elsevier Ltd. |
Chemical References |
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Topics |
- Administration, Inhalation
- Diketopiperazines
- Humans
- Lung
- Macrophages
- Particle Size
- Phagocytosis
- Pneumonia
(drug therapy)
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