Efficacy of pefloxacin-fosfomycin in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.

Abstract	The efficacies of pefloxacin, fosfomycin, and both of these agents in combination against methicillin-resistant Staphylococcus aureus were assessed in a rat endocarditis model. The combination prevented emergence of the fosfomycin and pefloxacin resistance seen in 36 and 4%, respectively, of animals receiving either agent alone and was more effective than either agent in sterilizing cardiac vegetations.
Authors	C Thauvin, J F Lemeland, G Humbert, J P Fillastre
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 32 Issue 6 Pg. 919-21 (Jun 1988) ISSN: 0066-4804 [Print] United States
PMID	3166360 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Infective Agents Pefloxacin Fosfomycin Norfloxacin Methicillin
Topics	Animals Anti-Infective Agents (therapeutic use) Endocarditis, Bacterial (drug therapy, microbiology) Fosfomycin (therapeutic use) Male Methicillin (pharmacology) Norfloxacin (analogs & derivatives, therapeutic use) Pefloxacin Penicillin Resistance Rats Rats, Inbred Strains Staphylococcal Infections (drug therapy, microbiology)

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