Clinical Effects of a Pectin-Containing Oligomeric Formula in Tube Feeding Patients: A Multicenter Randomized Clinical Trial.

Abstract

BACKGROUND:

A pectin-containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF.

METHODS:

The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management-related events.

RESULTS:

Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003).

CONCLUSIONS:

The results of this study suggest that POF is less likely to cause EN-related events, especially diarrhea, than SPF is.

• Authors: Michio Maruyama, Satoshi Goshi, Yasushige Kashima, Akihiro Mizuhara, Takashi Higashiguchi
• Journal: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition (Nutr Clin Pract) Vol. 35 Issue 3 Pg. 464-470 (Jun 2020) ISSN: 1941-2452 [Electronic] United States
• PMID: 31606903 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: © 2019 American Society for Parenteral and Enteral Nutrition.

Chemical References

• Pectins

Topics

• Aged
• Aged, 80 and over
• Diarrhea (epidemiology, prevention & control)
• Energy Intake
• Enteral Nutrition (adverse effects, methods)
• Female
• Food, Formulated (adverse effects, analysis)
• Gastrointestinal Diseases (epidemiology, prevention & control)
• Humans
• Male
• Pectins (administration & dosage)