Complete Pathological Response Following Radiochemotherapy for Locally Advanced Rectal Cancer: Short and Long-term Outcome.

Abstract

BACKGROUND/AIM:

Preoperative radiochemotherapy (RCT) followed by total mesorectum excision has become the gold standard for locally advanced carcinoma of the low and middle rectum. The aim of the study is to evaluate the short and long-term outcomes of patients in complete pathological response (PR) following this treatment sequence.

PATIENTS AND METHODS:

One hundred and thirty patients were retrospectively included between 2005 and 2017 in an expert centre, with 3 groups formed, according to the PR: i) complete PR (absence of tumour cells on the surgical specimen ypT0N0), ii) partial PR (T or N downsizing) and iii) without PR.

RESULTS:

The complete PR rate was 13.1%. The complete PR group tended to develop less symptomatic fistulas compared to partial PR and without PR groups (5.8% versus 13.5% versus 18.7, respectively; p=0.607). The 5-year disease-free survival was increased for complete-PR patients (93% versus 79% versus 47%, respectively; p=0.0003) without an improvement in overall survival.

CONCLUSION:

Complete PR is associated with an improvement in survival without recurrence and without an improvement in the overall survival at 5 years.

• Authors: Othman Iskander, Lise Courtot, Nicolas Tabchouri, Alice Artus, Nicolas Michot, Olivier Muller, Urs Pabst-Giger, Pascal Bourlier, Aurore Kraemer-Bucur, Thierry Lecomte, Serge Guyetant, Sophie Chapet, Gilles Calais, Ephrem Salamé, Mehdi Ouaïssi
• Journal: Anticancer research (Anticancer Res) Vol. 39 Issue 9 Pg. 5105-5113 (Sep 2019) ISSN: 1791-7530 [Electronic] Greece
• PMID: 31519622 (Publication Type: Journal Article)
• Copyright: Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Biopsy
• Chemoradiotherapy
• Colonoscopy
• Combined Modality Therapy
• Female
• Humans
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Metastasis
• Neoplasm Staging
• Rectal Neoplasms (diagnosis, mortality, pathology, therapy)
• Tomography, X-Ray Computed
• Treatment Outcome