Association between the XKR6 rs7819412 SNP and serum lipid levels and the risk of coronary artery disease and ischemic stroke.

Abstract

BACKGROUND:

The present study aimed to expound the association between the XK related 6 gene (XKR6) rs7819412 single nucleotide polymorphism (SNP) and serum lipid profiles and the risk of coronary artery disease (CAD) and ischemic stroke.

METHODS:

The genetic makeup of the XKR6 rs7819412 SNP in 1783 unrelated participants (controls, 643; CAD, 588 and ischemic stroke, 552) of Han Chinese was obtained by the Snapshot technology.

RESULTS:

The genotypic frequencies of the SNP were disparate between CAD (GG, 81.0%; GA/AA, 19.0%) or ischemic stroke (GG, 81.2%; GA/AA, 18.8%) patients and healthy controls (GG, 85.7%, GA/AA, 14.3%; P < 0.05 vs. CAD or ischemic stroke; respectively). The A allele frequency was also diverse between CAD (10.1%) or ischemic stroke (10.0%) and control groups (7.5%; P < 0.05 vs. CAD or ischemic stroke; respectively). The GA/AA genotypes and A allele were associated with high risk of CAD and ischemic stroke (CAD: P = 0.026 for GA/AA vs. GG, P = 0.024 for A vs. G; Ischemic stroke: P = 0.029 for GA/AA vs. GG, P = 0.036 for A vs. G). The GA/AA genotypes were also associated with increased serum triglyceride (TG) concentration in CAD and total cholesterol (TC) concentration in ischemic stroke patients.

CONCLUSIONS:

These data revealed that the XKR6 rs7819412 A allele was related to increased serum TG levels in CAD, TC levels in ischemic stroke patients and high risk of CAD and ischemic stroke.

• Authors: Peng-Fei Zheng, Rui-Xing Yin, Guo-Xiong Deng, Yao-Zong Guan, Bi-Liu Wei, Chun-Xiao Liu
• Journal: BMC cardiovascular disorders (BMC Cardiovasc Disord) Vol. 19 Issue 1 Pg. 202 (08 20 2019) ISSN: 1471-2261 [Electronic] England
• PMID: 31429711 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Membrane Proteins
• Triglycerides
• XKR6 protein, human
• Cholesterol

Topics

• Aged
• Biomarkers (blood)
• Brain Ischemia (blood, diagnostic imaging, genetics)
• Case-Control Studies
• Cholesterol (blood)
• Coronary Artery Disease (blood, diagnostic imaging, genetics)
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Male
• Membrane Proteins (genetics)
• Middle Aged
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Assessment
• Risk Factors
• Stroke (blood, diagnosis, genetics)
• Triglycerides (blood)