Nonvascularized human skin chronic allograft rejection.

Abstract

A 65-year-old man had extensive burns of the lower legs in 1991, at the age of 40 years. He was treated by nonvascularized and de-epithelialized, allogeneic split-thickness skin allograft and cyclosporine monotherapy for 2 months. Ulcers developed between 10 and 25 years after transplantation and a surgical debridement on the lower extremities was required. Analyses of the removed tissue allografts showed chronic antibody-mediated and cellular rejection with extensive and dense fibrosis, and diffuse capillary C4d deposits. An anti-DRB1*08:01, donor-specific antibody was present. A unique clinical condition with late immunopathological features of human skin chronic allograft rejection is reported.

• Authors: Samuel Rotman, Nathalie Koch, Lucie Wiesner, Vincent Aubert, Ivy A Rosales, Robert B Colvin, Wassim Raffoul, Manuel Pascual
• Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Am J Transplant) Vol. 19 Issue 11 Pg. 3191-3196 (11 2019) ISSN: 1600-6143 [Electronic] United States
• PMID: 31344327 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.

Chemical References

• Isoantibodies

Topics

• Aged
• Burns (therapy)
• Chronic Disease
• Graft Rejection (diagnosis, etiology)
• Graft Survival
• Humans
• Isoantibodies (adverse effects)
• Male
• Neovascularization, Pathologic (diagnosis, etiology)
• Prognosis
• Risk Factors
• Skin Transplantation (adverse effects)
• Transplantation, Homologous