Integrating Fluorinated Polymer and Manganese-Layered Double Hydroxide Nanoparticles as pH-activated 19 F MRI Agents for Specific and Sensitive Detection of Breast Cancer.
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| Abstract |
19 F magnetic resonance imaging (19 F MRI) agents capable of being activated upon interactions with cancer triggers are attracting increasing attention, although challenges still remain for precise and specific detection of cancer tissues. In this study, a novel hybrid 19 F MRI agent for pH-sensitive detection of breast cancer tissues is reported, a composite system designed by conjugating a perfluoropolyether onto the surface of manganese-incorporated layered double hydroxide (Mn-LDH@PFPE) nanoparticles. The 19 F NMR/MRI signals from aqueous solutions of Mn-LDH@PFPE nanoparticles are quenched at pH 7.4, but "turned on" following a reduction in pH to below 6.5. This is due to partial dissolution of Mn2+ from the Mn-LDH nanoparticles and subsequent reduction in the effect of paramagnetic relaxation. Significantly, in vivo experiments reveal that an intense 19 F MR signal can be detected only in the breast tumor tissue after intravenous injection of Mn-LDH@PFPE nanoparticles due to such a specific activation. Thus pH-activated Mn-LDH@PFPE nanoparticles are a potential "smart" 19 F MRI agent for precise and specific detection of cancer diseases.
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| Authors | Cheng Zhang, Li Li, Felicity Y Han, Xinying Yu, Xiao Tan, Changkui Fu, Zhi Ping Xu, Andrew K Whittaker |
| Journal | Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 15 Issue 36 Pg. e1902309 (09 2019) ISSN: 1613-6829 [Electronic] Germany |
| PMID | 31328398 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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