Production of ciprofloxacin loaded chitosan/gelatin/bone ash wound dressing with improved mechanical properties.

Abstract

Polymeric films with enhanced mechanical performance were fabricated by incorporation of bone ash (BA) at various concentrations (0-25 v. %) into chitosan/gelatin (CTS/GEL) polymeric structure as a wound healing-dressing. The test results for mechanical performance of polymeric films proved that the encapsulation of BA into the polymeric films enhances the elastic modulus and tensile strength of polymeric films significantly. Oxygen permeability and water vapor transmission rate (WVTR) of films were also improved by BA reinforcement. Ciprofloxacin was chosen as the antibacterial model drug. The release of ciprofloxacin was provided in a more controlled manner at pH 7.4 owing to the incorporation of bone ash into the polymeric films. Also, drug loaded films showed great antibacterial activity against Escherichia coli and Bacillus subtilis bacteria. The results prove that ciprofloxacin loaded BA reinforced CTS/GEL composite films are potentially applicable in controlled drug delivery as wound dressings.

• Authors: Begüm Evranos, Didem Aycan, Neslihan Alemdar
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 222 Pg. 115007 (Oct 15 2019) ISSN: 1879-1344 [Electronic] England
• PMID: 31320087 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Minerals
• Ciprofloxacin
• bone ash
• Gelatin
• Chitosan
• Oxygen

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Bacillus subtilis (drug effects)
• Bandages
• Cell Line
• Chitosan (chemistry, toxicity)
• Ciprofloxacin (pharmacology)
• Drug Liberation
• Elastic Modulus
• Escherichia coli (drug effects)
• Gelatin (chemistry, toxicity)
• Mice
• Microbial Sensitivity Tests
• Minerals (chemistry, toxicity)
• Oxygen (chemistry)
• Permeability
• Tensile Strength