Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity.

Abstract

Continued interest in bioactive alkaloids led to the isolation of four undescribed alkaloids along with 74 known ones from the aerial parts of Tabernaemontana bufalina Lour. The structures of the yet undescribed alkaloids were elucidated based on NMR, IR, UV, MS and CD spectroscopic data and X-ray crystal diffraction and, according to the plant source, named as taberhaines A-D (1-4). The known compounds comprised of 66 monoterpenoid indole, three carboline and five isoquinoline alkaloids. Among them, the known apparicine inhibited significantly the activity of xanthine oxidase, which plays an important role for gout, with an IC50 value of 0.65 μM, compared to the standard drug allopurinol (IC50 = 0.60 μM).

• Authors: Bao-Bao Shi, Jing Chen, Mei-Fen Bao, Ying Zeng, Xiang-Hai Cai
• Journal: Phytochemistry (Phytochemistry) Vol. 166 Pg. 112060 (Oct 2019) ISSN: 1873-3700 [Electronic] England
• PMID: 31302343 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier Ltd. All rights reserved.

Chemical References

• Alkaloids
• Enzyme Inhibitors
• Xanthine Oxidase

Topics

• Alkaloids (chemistry, isolation & purification, pharmacology)
• Catalytic Domain
• Enzyme Inhibitors (chemistry, isolation & purification, pharmacology)
• Inhibitory Concentration 50
• Models, Molecular
• Tabernaemontana (chemistry)
• Xanthine Oxidase (antagonists & inhibitors, chemistry)