A Case of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Aspergillus Brain Abscess and Invasive Pulmonary Aspergillosis Successfully Treated with Voriconazole Followed by Cord Blood Transplantation.

Abstract

A 59-year-old female was diagnosed as pulmonary aspergillosis(IPA)while remission induction therapy for Philadelphia chromosome-positive acute lymphoblastic leukemia. Liposomal amphotericin B improved the fungal serodiagnostic markers, however,the IPA worsened. She also developed an Aspergillus brain abscess,which, while being undetectable on CT,was detected as multiple nodular lesions by MRI. A definitive diagnosis was made by polymerase chain reaction(PCR)of brain biopsy specimens. Voriconazole(VRCZ)was effective,and cord blood transplantation was performed. She has received VRCZ for a long time. There are no relapse of either the IPA or the Aspergillus brain abscess.

• Authors: Yasunobu Sekiguchi, Mutsumi Wakabayashi, Haruko Takizawa, Hiroko Iizuka, Sakura Sakajiri, Keiji Sugimoto, Tadaaki Inano, Yasutaka Fukuda, Yasuharu Hamano, Shigeki Tomita, Hiroshi Izumi, Mitsuo Okubo, Noriko Nakamura, Tomohiro Sawada, Masaaki Noguchi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 46 Issue 7 Pg. 1203-1209 (Jul 2019) ISSN: 0385-0684 [Print] Japan
• PMID: 31296832 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• Voriconazole

Topics

• Antifungal Agents
• Brain Abscess
• Cord Blood Stem Cell Transplantation
• Female
• Humans
• Invasive Pulmonary Aspergillosis (complications)
• Middle Aged
• Philadelphia Chromosome
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (complications, therapy)
• Voriconazole