Predictors and Outcomes of Persistent Tricuspid Regurgitation After Transcatheter Aortic Valve Implantation.

Abstract

Persistent tricuspid regurgitation (TR) after transcatheter aortic valve implantation (TAVI) has been reported to increase mortality. The aim of this study was to investigate clinical and echocardiographic determinants and outcome of persistent TR after TAVI. We reviewed 1,085 patients who underwent TAVI. Among them, 100 patients who had ≥moderate TR without organic dysfunction of the tricuspid valve apparatus were studied. Preprocedural and follow-up transthoracic echocardiography after TAVI were analyzed. After TAVI, patients were divided into persistent TR group and improved TR group. Clinical event was defined as all-cause mortality and readmission for heart failure within 1,000 days. Fifty-three (53%) patients had persistent TR, whereas 47 (47%) patients had improved TR. Risk of clinical event was significantly higher in the persistent TR group compared with the improved TR group. Atrial fibrillation (AF) and tricuspid annular dimension (TAD; p <0.05 for all) were independent predictors of persistent TR. Receiver operating characteristic curve showed the optimal cut-off value of TAD for predicting persistent TR was 37 mm. The combination of AF and TAD ≥37 mm was associated with persistent TR (p <0.001). In conclusion, AF and dilated TAD before TAVI predicted persistent TR which was associated with higher all-cause mortality and readmission for heart failure.

• Authors: Jun Yoshida, Hiroki Ikenaga, Atsushi Hayashi, Satoshi Yamaguchi, Takafumi Nagaura, Florian Rader, Robert J Siegel, Raj R Makkar, Takahiro Shiota
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 124 Issue 5 Pg. 772-780 (09 01 2019) ISSN: 1879-1913 [Electronic] United States
• PMID: 31280838 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Topics

• Age Factors
• Aged
• Aged, 80 and over
• Analysis of Variance
• Aortic Valve Stenosis (diagnostic imaging, mortality, surgery)
• Cause of Death
• Chronic Disease
• Cohort Studies
• Echocardiography (methods)
• Female
• Follow-Up Studies
• Humans
• Kaplan-Meier Estimate
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Predictive Value of Tests
• Prevalence
• Retrospective Studies
• Risk Assessment
• Severity of Illness Index
• Sex Factors
• Survival Analysis
• Time Factors
• Transcatheter Aortic Valve Replacement (adverse effects, methods)
• Tricuspid Valve Insufficiency (diagnostic imaging, etiology, mortality)