Abstract | AIMS: METHODS: Serum anti-PLA2R antibodies and glomerular PLA2R staining were assessed in 36 patients with malignancy-associated MN, followed by examination of serum anti-THSD7A antibodies and glomerular THSD7A. THSD7A staining in cancer tissues was also assessed in 9 of the 36 patients. RESULTS: Twelve (33%) of 36 patients were positive for both glomerular PLA2R and serum anti-PLA2R antibodies, one of whom had enhanced glomerular THSD7A staining. Two patients were positive for either glomerular PLA2R or serum anti-PLA2R antibody. All these patients had IgG4-dominant deposits in glomeruli. Among the 22 (61%) patients who were double negative for glomerular PLA2R and serum anti-PLA2R antibodies, 17 of 20 (85%) had IgG1-dominant deposits in glomeruli, and 2 (9.1%) were positive for glomerular THSD7A staining. Serum anti-THSD7A antibody was not detected in any of the 36 patients. Among the nine patients with available cancer tissues, positive staining of THSD7A in the cancer tissues was observed in five (56%) patients, and one showed enhanced glomerular staining of THSD7A. CONCLUSIONS: Screening of glomerular PLA2R antigen and serum anti-PLA2R antibodies is necessary in patients with malignancy-associated MN, whereas the incidence of glomerular THSD7A antigen or circulating anti-THSD7A antibodies is uncommon.
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Authors | Changming Zhang, Mingchao Zhang, Dacheng Chen, Qiang Ren, Weiwei Xu, Caihong Zeng, Weisong Qin, Zhihong Liu |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 72
Issue 10
Pg. 705-711
(Oct 2019)
ISSN: 1472-4146 [Electronic] England |
PMID | 31243053
(Publication Type: Journal Article)
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Copyright | © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. |
Chemical References |
- Immunoglobulin G
- PLA2R1 protein, human
- Receptors, Phospholipase A2
- THSD7A protein, human
- Thrombospondins
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Topics |
- Female
- Glomerulonephritis, Membranous
(enzymology, pathology)
- Humans
- Immunoglobulin G
(blood)
- Male
- Neoplasms
- Receptors, Phospholipase A2
(metabolism)
- Thrombospondins
(metabolism)
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