An All-Organic Semiconductor C3 N4 /PDINH Heterostructure with Advanced Antibacterial Photocatalytic Therapy Activity.

Abstract

Antibacterial photocatalytic therapy has been reported as a promising alternative water disinfection technology for combating antibiotic-resistant bacteria. Numerous inorganic nanosystems have been developed as antibiotic replacements for bacterial infection treatment, but these are limited due to the toxicity risk of heavy metal species. Organic semiconductor photocatalytic materials have attracted great attention due to their good biocompatibility, chemically tunable electronic structure, diverse structural flexibility, suitable band gap, low cost, and the abundance of the resources they require. An all-organic composite photocatalytic nanomaterial C3 N4 /perylene-3,4,9,10-tetracarboxylic diimide (PDINH) heterostructure is created through recrystallization of PDINH on the surface of C3 N4 in situ, resulting in enhanced photocatalytic efficiency due to the formation of a basal heterostructure. The absorption spectrum of this composite structure can be extended from ultraviolet to near-infrared light (750 nm), enhancing the photocatalytic effect to produce more reactive oxygen species, which have an excellent inactivation effect on both Gram-negative and positive bacteria, while demonstrating negligible toxicity to normal tissue cells. An efficient promotion of infectious wound regeneration in mice with Staphylococcus aureus infected dermal wounds is demonstrated. This all-organic heterostructure shows great promise for use in wound disinfection.

• Authors: Longwei Wang, Xiao Zhang, Xin Yu, Fene Gao, Ziyi Shen, Xiaolei Zhang, Shenguang Ge, Jing Liu, Zhanjun Gu, Chunying Chen
• Journal: Advanced materials (Deerfield Beach, Fla.) (Adv Mater) Vol. 31 Issue 33 Pg. e1901965 (Aug 2019) ISSN: 1521-4095 [Electronic] Germany
• PMID: 31237375 (Publication Type: Journal Article)
• Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Anti-Bacterial Agents
• Imides
• Nitriles
• Photosensitizing Agents
• Porphyrins
• Reactive Oxygen Species
• perylenetetracarboxylic diimide
• cyanogen
• Perylene

Topics

• Animals
• Anti-Bacterial Agents (chemistry, therapeutic use, toxicity)
• Catalysis
• Cell Survival
• Escherichia coli (drug effects)
• Female
• Imides (chemistry)
• Light
• Mice
• Mice, Inbred BALB C
• NIH 3T3 Cells
• Nanostructures (chemistry)
• Nitriles (chemistry, therapeutic use, toxicity)
• Perylene (analogs & derivatives, chemistry)
• Photochemotherapy (methods)
• Photosensitizing Agents (chemistry, therapeutic use, toxicity)
• Porphyrins (therapeutic use, toxicity)
• Reactive Oxygen Species (metabolism)
• Semiconductors
• Staphylococcus aureus (drug effects)
• Wound Healing
• Wound Infection (drug therapy, microbiology)