The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs.

Abstract

The study aimed to define the effects of M. haemolytica and a single oral dose of albendazole on the single-dose pharmacokinetics of marbofloxacin in lambs. The pharmacokinetic-pharmacodynamic integration of marbofloxacin was applied to describe a 3 mg/kg intramuscular dose in lambs. The 6 healthy and 12 naturally infected with M. haemolytica lambs (Akkaraman, males weighing 10-15 kg and aged 2-3 months) were used in this study. In the marbofloxacin group, 6 healthy lambs received marbofloxacin. In the albendazole group after 2 weeks washout period, the same animals received marbofloxacin on 1 h after albendazole. In the diseased marbofloxacin group, 6 lambs naturally infected with M. haemolytica received marbofloxacin. In the diseased albendazole group, 6 lambs naturally infected with M. haemolytica received marbofloxacin on 1 h after albendazole. The marbofloxacin and albendazole were administered each as a single dose of 3 mg/kg intramuscular and 7.5 mg/kg oral, respectively, in the respective groups. Plasma concentration of marbofloxacin was measured with HPLC-UV and pharmacokinetic parameters were analyzed by non-compartmental model. Albendazole did not change the pharmacokinetic profiles of marbofloxacin in healthy and diseased lambs. However, M. haemolytica affected the pharmacokinetics of marbofloxacin in diseased lambs, AUC0-24/MIC90 ratio was not found to be higher than 125, but Cmax/MIC90 ratios was found to be higher than 10 for an MIC value of 0.25 μg/mL in all groups. The marbofloxacin dose described in this study may not be effective for the treatment of infections due to M. haemolytica in lambs, with MIC ≤ 0.25 μg/mL.

• Authors: Feray Altan, Duygu Neval Sayin Ipek, Orhan Corum, Simten Yesilmen Alp, Polat Ipek, Kamil Uney
• Journal: Tropical animal health and production (Trop Anim Health Prod) Vol. 51 Issue 8 Pg. 2603-2610 (Nov 2019) ISSN: 1573-7438 [Electronic] United States
• PMID: 31230255 (Publication Type: Journal Article)

Chemical References

• Anthelmintics
• Anti-Bacterial Agents
• Fluoroquinolones
• marbofloxacin
• Albendazole

Topics

• Albendazole (pharmacology)
• Animals
• Anthelmintics (pharmacology)
• Anti-Bacterial Agents (pharmacokinetics)
• Fluoroquinolones (pharmacokinetics)
• Injections, Intramuscular (veterinary)
• Male
• Mannheimia haemolytica (physiology)
• Pasteurellosis, Pneumonic (drug therapy, microbiology)
• Sheep
• Sheep Diseases (drug therapy, microbiology)
• Turkey