Abstract | OBJECTIVES: METHODS: The United Network for Organ Sharing Registry was queried for first-time, adult recipients of heart transplant from 2006 to 2018. Cox proportional hazards with penalized smooth splines was used to stratify patients based on donor brain death interval: shorter (<22 hours), reference (22-42 hours), and longer (>42 hours). Overall survival was estimated using Kaplan-Meier and Cox proportional hazards models. RESULTS: A total of 22,960 patients met study criteria (9.2% shorter, 55.0% reference, and 35.8% longer). Longer brain death duration recipients were more likely to have a later year of transplant and have a mechanical bridge to transplant, whereas longer duration donors were more likely to be black and die of anoxia compared with shorter duration and reference donors. Compared with reference, neither shorter (hazard ratio, 1.02; 95% confidence interval, 0.94-1.12) nor longer donor brain death interval (hazard ratio, 1.01; 95% CI, 0.94-1.08) was associated with posttransplant survival in either unadjusted or multivariable analyses (both P values >0.6). CONCLUSIONS:
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Authors | Oliver K Jawitz, Vignesh Raman, Yaron D Barac, Jatin Anand, Chetan B Patel, Robert J Mentz, Adam D DeVore, Carmelo Milano |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 159
Issue 4
Pg. 1345-1353.e2
(04 2020)
ISSN: 1097-685X [Electronic] United States |
PMID | 31147170
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2019 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved. |
Topics |
- Adult
- Brain Death
- Female
- Heart Failure
(etiology, mortality, surgery)
- Heart Transplantation
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Proportional Hazards Models
- Registries
- Survival Rate
- Tissue and Organ Procurement
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