Abstract |
The clinical treatment of bone tumors usually brings about residual tumor cells and large bone defects after tumor removal surgery. To solve this problem, it is imperative to develop a novel implant with bi-functions for eliminating the residual tumor cells and repairing bone defects. In this study, hydrogenated black TiO2 (H-TiO2) coating with hierarchical micro/nano-topographies is fabricated by induction suspension plasma spraying (ISPS). The fabricated H-TiO2 coating possessed excellent and controllable photothermal effect in inhibiting the tumor growth under 808 nm NIR laser irradiation in vitro and in vivo. The hierarchical hybrid micro/nano-structured surface and Ti- OH groups improved the adhesion, proliferation, differentiation and osteogenic gene expressions of rat bone mesenchymal stem cells (rBMSCs). These results demonstrate that the H-TiO2 coating may be a promising implant material for the treatment of bone tumors and bone regeneration.
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Authors | Wenxin Zhang, Jingping Gu, Kai Li, Jun Zhao, Hongshi Ma, Chengtie Wu, Cheng Zhang, Youtao Xie, Fei Yang, Xuebin Zheng |
Journal | Materials science & engineering. C, Materials for biological applications
(Mater Sci Eng C Mater Biol Appl)
Vol. 102
Pg. 458-470
(Sep 2019)
ISSN: 1873-0191 [Electronic] Netherlands |
PMID | 31147017
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier B.V. All rights reserved. |
Chemical References |
- Coated Materials, Biocompatible
- titanium dioxide
- Titanium
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Topics |
- Animals
- Bone Neoplasms
(pathology, therapy)
- Bone Regeneration
(drug effects)
- Cell Adhesion
(drug effects)
- Cell Differentiation
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Coated Materials, Biocompatible
(pharmacology)
- Humans
- Hydrogenation
- Hyperthermia, Induced
- Mesenchymal Stem Cells
(cytology, drug effects, ultrastructure)
- Mice, Inbred BALB C
- Mice, Nude
- Osteogenesis
(drug effects)
- Photoelectron Spectroscopy
- Phototherapy
- Rats
- Titanium
(pharmacology)
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