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A hydrogenated black TiO2 coating with excellent effects for photothermal therapy of bone tumor and bone regeneration.

Abstract
The clinical treatment of bone tumors usually brings about residual tumor cells and large bone defects after tumor removal surgery. To solve this problem, it is imperative to develop a novel implant with bi-functions for eliminating the residual tumor cells and repairing bone defects. In this study, hydrogenated black TiO2 (H-TiO2) coating with hierarchical micro/nano-topographies is fabricated by induction suspension plasma spraying (ISPS). The fabricated H-TiO2 coating possessed excellent and controllable photothermal effect in inhibiting the tumor growth under 808 nm NIR laser irradiation in vitro and in vivo. The hierarchical hybrid micro/nano-structured surface and Ti-OH groups improved the adhesion, proliferation, differentiation and osteogenic gene expressions of rat bone mesenchymal stem cells (rBMSCs). These results demonstrate that the H-TiO2 coating may be a promising implant material for the treatment of bone tumors and bone regeneration.
AuthorsWenxin Zhang, Jingping Gu, Kai Li, Jun Zhao, Hongshi Ma, Chengtie Wu, Cheng Zhang, Youtao Xie, Fei Yang, Xuebin Zheng
JournalMaterials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 102 Pg. 458-470 (Sep 2019) ISSN: 1873-0191 [Electronic] Netherlands
PMID31147017 (Publication Type: Journal Article)
CopyrightCopyright © 2019 Elsevier B.V. All rights reserved.
Chemical References
  • Coated Materials, Biocompatible
  • titanium dioxide
  • Titanium
Topics
  • Animals
  • Bone Neoplasms (pathology, therapy)
  • Bone Regeneration (drug effects)
  • Cell Adhesion (drug effects)
  • Cell Differentiation (drug effects)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Cell Survival (drug effects)
  • Coated Materials, Biocompatible (pharmacology)
  • Humans
  • Hydrogenation
  • Hyperthermia, Induced
  • Mesenchymal Stem Cells (cytology, drug effects, ultrastructure)
  • Mice, Inbred BALB C
  • Mice, Nude
  • Osteogenesis (drug effects)
  • Photoelectron Spectroscopy
  • Phototherapy
  • Rats
  • Titanium (pharmacology)

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