Sinonasal undifferentiated carcinoma: clinicopathological spectrums and diagnosis reappraisal.

Abstract

Sinonasal undifferentiated carcinoma (SNUC) is defined as undifferentiated carcinoma of the sinonasal tract without glandular or squamous features and not otherwise classifiable. SNUC is a rare tumor, with a long list of differential diagnoses, and often poses a considerable diagnostic challenge. In addition, recent advances in molecular and immunohistochemistry techniques have recognized several new entities that were previously included in the SNUC category. These include SMARCB1 (INI-1)-deficient carcinoma, NUT (nuclear protein in testis) carcinoma, adamantinoma-like Ewing sarcoma, and the most recently described and rarer SMARCA4 (BRG)-deficient carcinoma. In this study, we retrospectively reviewed 11 cases with an original diagnosis of SNUC. We found that a significant portion of those cases can be reclassified into specific entities, with potential impact on therapy and prognosis because of misclassification in 2 of these cases.

• Authors: Elmira Vaziri Fard, Songlin Zhang, Zhenjian Cai, Jianmin Ding, Qigang Sun, Karan Saluja, Hui Zhu
• Journal: Human pathology (Hum Pathol) Vol. 89 Pg. 62-70 (07 2019) ISSN: 1532-8392 [Electronic] United States
• PMID: 31054892 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Carcinoma (classification, diagnosis, pathology)
• Diagnosis, Differential
• Female
• Humans
• Male
• Maxillary Sinus Neoplasms (classification, diagnosis, pathology)
• Middle Aged
• Paranasal Sinus Neoplasms (classification, diagnosis, pathology)
• Retrospective Studies
• Young Adult