First Case Report of Intraventricular Tigecycline in a Neonate With Extensively Drug-resistant Acinetobacter baumannii Ventriculitis.

Abstract

Multidrug-resistant and extensively drug-resistant Acinetobacter baumannii infections have been increasing as a cause of healthcare-associated infections in the neonatal age group. In this report, we describe a 27-week, 1028 g, preterm neonate with extensively drug-resistant A. baumannii infection complicated by ventriculitis who did not respond to intravenous and intraventricular colistin but did respond after intraventricular tigecycline. This is the first case report describing the use of intraventricular tigecycline in a neonate with ventriculitis.

• Authors: Rathna Pratheep, Somosri Ray, Kanya Mukhopadhyay, Vikas Gautam, Nusrat Shafiq, Sourabh Dutta, Shiv Sajan Saini, Anmol Bhatia
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 38 Issue 8 Pg. e172-e174 (08 2019) ISSN: 1532-0987 [Electronic] United States
• PMID: 31033908 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Biomarkers
• Tigecycline

Topics

• Acinetobacter Infections (diagnosis, drug therapy, microbiology)
• Acinetobacter baumannii (drug effects)
• Anti-Bacterial Agents (administration & dosage)
• Biomarkers
• Cerebral Ventriculitis (diagnosis, drug therapy, microbiology)
• Drug Resistance, Multiple, Bacterial
• Female
• Humans
• Infant, Newborn
• Infant, Premature
• Injections, Intraventricular
• Microbial Sensitivity Tests
• Tigecycline (administration & dosage)
• Treatment Outcome
• Ultrasonography