Abstract |
Hodgkin's disease and mycosis fungoides have been rarely reported in the same patient. This coexistence has been debated in the medical literature. We studied such a patient and report, to our knowledge, the first immunophenotypic evidence for such a coexistence. Reed-Sternberg cells and their variants stained with anti-Leu-M1, Hefi-1, anti-Tac, anti- HLA-DR, and OKT9, but were negative for T cell markers 3A1, Leu-1, Leu-2a, and Leu-3a, a phenotype typical of Hodgkin's disease; infiltrating small lymphocytes were predominantly T cells and were phenotypically normal. In the skin lesions, cells with the phenotype of Hodgkin's disease were not present; the infiltrate was composed of helper T lymphocytes that were 3A1-negative, a phenotype characteristic of the malignant cells of mycosis fungoides. Unexpectedly, a dermatopathic lymph node from the same patient showed the presence of the Leu-M1 antigen on the majority of normal-appearing interdigitating reticulum cells; this was not the case with control dermatopathic lymph nodes from patients without a malignancy. The significance, implications, and possible interrelationships of the findings are discussed.
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Authors | C R Simrell, R V Boccia, D L Longo, E S Jaffe |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 110
Issue 11
Pg. 1029-34
(Nov 1986)
ISSN: 0003-9985 [Print] United States |
PMID | 3096258
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Neoplasm
- Antigens, Surface
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Topics |
- Adult
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Neoplasm
(analysis)
- Antigens, Surface
(analysis)
- Hodgkin Disease
(complications, pathology)
- Humans
- Immunoenzyme Techniques
- Lymph Nodes
(pathology)
- Male
- Mycosis Fungoides
(complications, pathology)
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