Aripiprazole-induced persistent hiccup: a case report and review of the literature.

Abstract

Aripiprazole is an interesting psychoactive compound acting as a dopamine D2 partial agonist, serotonin 5-HT(1A) partial agonist and serotonin 5-HT(2A) antagonist. Aripiprazole possesses a well-documented efficacy in the treatment of both positive and negative psychotic symptoms. However, this medication may be rarely associated with the onset of hiccup. Here, we present the case of aripiprazole-induced hiccup in a young inpatient at his first psychiatric admission together with a review of the current literature about this topic. The possible etiology underlying the emergence of hiccups together with the clinical implications of this adverse event are discussed.

• Authors: Gianluca Serafini, Giulia Piccinini, Samantha Visimberga, Alice Cervetti, Martino Belvederi Murri, Fiammetta Monacelli, Maurizio Pompili, Mario Amore
• Journal: Psychiatria Danubina (Psychiatr Danub) Vol. 31 Issue 1 Pg. 26-31 (Mar 2019) ISSN: 0353-5053 [Print] Croatia
• PMID: 30948686 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antipsychotic Agents
• Piperazines
• Quinolones
• Aripiprazole

Topics

• Antipsychotic Agents (adverse effects)
• Aripiprazole (adverse effects)
• Hiccup (chemically induced)
• Humans
• Piperazines
• Quinolones