Plasma histamine elevation in a large cohort of sickle cell disease patients.

Abstract

The role of mast cells has been questioned in sickle cell disease (SCD). We performed a prospective study evaluating plasma histamine and tryptase levels in a cohort of paediatric and adult patients, in steady state (n = 132) and during vaso-occlusive crisis (VOC) (n = 121). Histamine level was elevated in 18% of patients in steady state and in 61% during VOC. Median histamine level was significantly higher during VOC than in steady state (24·1 [7·0-45·0] vs 9·6 [6·2-14·4] nmol/l, P < 0·0001). Tryptase level was slightly increased during VOC without reaching pathological values. These results suggest a role of mast cell activation in SCD pathophysiology.

• Authors: Slimane Allali, François Lionnet, Sarah Mattioni, Jacques Callebert, Katia Stankovic Stojanovic, Claude Bachmeyer, Jean-Benoit Arlet, Valentine Brousse, Mariane de Montalembert, Martin Chalumeau, Gilles Grateau, Thiago T Maciel, Jean-Marie Launay, Olivier Hermine, Sophie Georgin-Lavialle
• Journal: British journal of haematology (Br J Haematol) Vol. 186 Issue 1 Pg. 125-129 (07 2019) ISSN: 1365-2141 [Electronic] England
• PMID: 30924132 (Publication Type: Journal Article)
• Copyright: © 2019 British Society for Haematology and John Wiley & Sons Ltd.

Chemical References

• Histamine
• Tryptases

Topics

• Adult
• Anemia, Sickle Cell (blood, complications, pathology)
• Child
• Cohort Studies
• Female
• Histamine (blood)
• Humans
• Male
• Mast Cells (metabolism)
• Prospective Studies
• Tryptases (blood)
• Vascular Diseases (blood, etiology)