Abstract | PURPOSE: METHODS: The study included 20 eyes from 20 Caucasian patients with unilateral neovascular AMD and 20 fellow eyes. All eyes were treated with standard intravitreal injection of aflibercept (IVA). Measurements of blood flow at the optic nerve head (ONH) and the choroid were performed with laser speckle flowgraphy (LSFG). The intraocular pressure (IOP), systolic and diastolic blood pressure, heart rate, mean arterial pressure (MAP) and ocular perfusion pressure ( OPP) were analysed. Measurements were performed at baseline and repeated immediately after the injection and 30 and 45 min later. RESULTS: Mean time between injection of aflibercept and first follow-up was 8:56 ± 4:25 min. The injection led to significant rise in IOP. In the injected eyes, mean blur rate (MBR, i.e. a relative measure of perfusion and the main outcome parameter of LSFG) within the major vessels of the ONH as well as at the entire ONH region decreased significantly (p < 0.001). No change in MBR was observed in the fellow eye. Choroidal blood flow was maintained stable in both eyes. CONCLUSION:
Intravitreal injection of aflibercept (IVA) led to a short-term reduction in perfusion only in the treated eye. This was independent from IOP, indicating a direct pharmacological effect. No changes in choroidal perfusion were observed during the first 45 min after the injection.
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Authors | Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer, Matthias Bolz |
Journal | Acta ophthalmologica
(Acta Ophthalmol)
Vol. 97
Issue 6
Pg. e927-e932
(Sep 2019)
ISSN: 1755-3768 [Electronic] England |
PMID | 30916896
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2019 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation. |
Chemical References |
- Recombinant Fusion Proteins
- aflibercept
- Receptors, Vascular Endothelial Growth Factor
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Topics |
- Aged
- Choroid
(blood supply)
- Female
- Follow-Up Studies
- Humans
- Intravitreal Injections
- Laser-Doppler Flowmetry
- Male
- Optic Disk
(blood supply)
- Prospective Studies
- Receptors, Vascular Endothelial Growth Factor
(administration & dosage, antagonists & inhibitors)
- Recombinant Fusion Proteins
(administration & dosage)
- Regional Blood Flow
(physiology)
- Retinal Vessels
(diagnostic imaging, physiopathology)
- Treatment Outcome
- Visual Acuity
- Wet Macular Degeneration
(drug therapy)
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