Prognostic significance of lncRNA DANCR expression in human cancers: a systematic review and meta-analysis.

Abstract

Several studies demonstrated that lncRNA differentiation antagonizing non-protein coding RNA (lncRNA DANCR) expression might have the potential capacity to predict the cancer prognosis; however, definite conclusion has not been obtained. The aim of this meta-analysis was to evaluate the prognostic value of lncRNA DANCR expression in cancers. PubMed, Web of Science, Scopus, and Embase were comprehensively searched for relevant studies. Studies meeting all inclusion standards were included into this meta-analysis. The analysis of overall survival (OS), disease-free survival (DFS), or clinicopathological features was conducted. Total 11 studies containing 1154 cancer patients were analyzed in this meta-analysis. The results showed, compared with low lncRNA DANCR expression, high lncRNA DANCR expression was significantly associated with shorter OS (hazard ratio [HR] = 1.85; 95% CI = 1.52-2.26; P<0.01) and DFS (HR = 1.82; 95% CI = 1.43-2.32; P<0.01) in cancers. Besides, high lncRNA DANCR expression predicted deeper tumor invasion (P<0.01), earlier lymph node metastasis (P<0.01), earlier distant metastasis (P<0.01), and more advanced clinical stage (P<0.01) compared with low lncRNA DANCR expression in cancer populations. High lncRNA DANCR expression was associated with worse prognosis compared with low lncRNA DANCR expression in cancers. LncRNA DANCR expression could serve as a prognostic factor of human cancers.

• Authors: Wei Liu, Qin-Peng Wang, Jia Guo
• Journal: Bioscience reports (Biosci Rep) Vol. 41 Issue 8 (08 27 2021) ISSN: 1573-4935 [Electronic] England
• PMID: 30910838 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)
• Copyright: © 2021 The Author(s).

Chemical References

• Biomarkers, Tumor
• DANCR long noncoding RNA, human
• RNA, Long Noncoding

Topics

• Biomarkers, Tumor (genetics, metabolism)
• Disease-Free Survival
• Gene Expression Regulation, Neoplastic
• Humans
• Lymphatic Metastasis
• Neoplasm Invasiveness
• Neoplasm Staging
• Neoplasms (genetics, metabolism, pathology, therapy)
• Predictive Value of Tests
• RNA, Long Noncoding (genetics, metabolism)
• Signal Transduction