Mechanisms and therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy.

Abstract

Immunotherapies based on T cells have gained significant success in the treatment of diverse cancers, however, several limitations also exist, including low response, acquired resistance and severe side effects, which lead to unfavorable outcomes. Recent studies found that traditional therapies, radiotherapy and/or chemotherapy may affect the immune condition in situ and cause abscopal effect, which may improve the response of immunotherapies, enhance the efficiency, and reduce the untoward effect. Here, we review the mechanisms uncovering the cancer immunotherapy and immunogenic effects of radiotherapy and chemotherapy, aiming to highlight the principles underlying the therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy and ultimately guide better designs for future synergistic cancer therapies.

• Authors: Wei-Di Yu, Guan Sun, Jun Li, Jiang Xu, Xiaochen Wang
• Journal: Cancer letters (Cancer Lett) Vol. 452 Pg. 66-70 (06 28 2019) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 30902563 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents, Immunological
• Cancer Vaccines

Topics

• Animals
• Antineoplastic Agents, Immunological (adverse effects, therapeutic use)
• Cancer Vaccines (adverse effects, therapeutic use)
• Chemotherapy, Adjuvant
• Humans
• Immunotherapy (adverse effects, methods)
• Immunotherapy, Adoptive (adverse effects)
• Lymphocytes, Tumor-Infiltrating (drug effects, immunology, radiation effects)
• Neoplasms (immunology, pathology, therapy)
• Radiotherapy, Adjuvant
• T-Lymphocytes (drug effects, immunology, radiation effects)
• Tumor Escape
• Tumor Microenvironment