[Meningococcal sepsis without cerebrospinal fluid abnormalities under treatment with eculizumab].

Abstract

Infections with Neisseriameningitidis are life-threatening conditions, generally presenting as meningitis. This case of a young woman who had a history of paroxysmal nocturnal hemoglobinuria under treatment with the complement inhibitor eculizumab had been presented with septic shock. While blood cultures were positive for Neisseria meningitidis, she showed no evidence for bacterial meningitis in the cerebrospinal fluid. This case shows that meningococcal sepsis without signs for bacterial meningitis despite repetitive vaccinations is possible in adults under eculizumab.

• Authors: Madlen Jentzsch, Sebastian Schwind, Vladan Vucinic, Sebastian Wendt, Catalina-Suzana Stingu, Dietger Niederwieser, Lorenz Weidhase
• Journal: Medizinische Klinik, Intensivmedizin und Notfallmedizin (Med Klin Intensivmed Notfmed) Vol. 115 Issue 4 Pg. 340-342 (May 2020) ISSN: 2193-6226 [Electronic] Germany
• Vernacular Title: Meningokokkensepsis ohne Liquorpathologie unter Eculizumabtherapie.
• PMID: 30848313 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal, Humanized
• eculizumab

Topics

• Adult
• Antibodies, Monoclonal, Humanized (adverse effects)
• Female
• Hemoglobinuria, Paroxysmal
• Humans
• Meningitis, Meningococcal (diagnosis)
• Meningococcal Infections (diagnosis, drug therapy)
• Shock, Septic