Abstract | AIM: MATERIAL AND METHODS: Four groups of primary ischemic stroke (IS) patients (n=80; 62±0.2 y.o., verified by MRI), including controls, admitted to Stroke Unit 24 h after stroke in the area of RAM (29.5%), and LAM (70.5%), were studied. Basic therapy was provided according to National Stroke Treatment Recommendations, treated groups received ChA 14 mg/kg (2st gr.), SC 0.5 mg/kg (3nd gr.), combination of two compounds (3d gr.). Controls (4th gr.) received placebo. Pharmacological treatment was provided for 10 days with continuation by oral administration. Dysphagia was measured semi-quantitively by MASA scale, three scale determinants were measured on admission, on 5 and 13 days of stay in the hospital. RESULTS AND CONCLUSION: The differences were significant and observed on the 5th day of treatment. ChA mostly improved sip control, and larynx movements (38% above controls; p<0.01), while SC improved the closure of vocal cords (55% above controls; p<0.01). This may reflect the differences in synaptic control of these functions. Combined treatment was more effective than monotherapy: 15% above ChA, and 21% above SC for swallowing function (p=0.01); 33 and 22% for vocal closure, 37% (p=0.05) and 76% (p=0.01) for larynx movement, which may be due to synergism between two medications. Therefore, sip, larynx, and swallowing exercises with pharmacological support of ChA and SC ameliorated dysphagia after IS.
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Authors | I N Balashova, N P Vanchakova, V V Afanasiev, E R Barantzevich, E L Pugacheva, K V Golikov |
Journal | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
(Zh Nevrol Psikhiatr Im S S Korsakova)
2018
Vol. 118
Issue 12. Vyp. 2
Pg. 64-69
ISSN: 1997-7298 [Print] Russia (Federation) |
Vernacular Title | Diagnostika i lechenie neĭrogennoĭ disfagii u bol'nykh, perenesshikh ostryĭ karotidnyĭ ishemicheskiĭ insul't. |
PMID | 30830119
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Glycerylphosphorylcholine
- Succinic Acid
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Topics |
- Brain Ischemia
(complications)
- Deglutition
- Deglutition Disorders
(diagnosis, drug therapy, etiology)
- Glycerylphosphorylcholine
(therapeutic use)
- Humans
- Stroke
(complications)
- Succinic Acid
(therapeutic use)
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