Single-dose ceftriaxone therapy of gonococcal ophthalmia neonatorum.

Abstract

Ceftriaxone (125 mg) given as a single intramuscular dose without topical therapy was evaluated in seven infants with smear-positive gonococcal ophthalmia neonatorum. Neisseria gonorrhoeae was isolated from the eyes of six infants, and four of these isolates were penicillinase-producing N. gonorrhoeae. Two infants had concomitant ocular infection with Chlamydia trachomatis. All seven infants, when seen at follow-up, showed marked clinical improvement. Conjunctivitis resolved completely in four infants. One infant was lost to subsequent follow-up, while two infants had persistent ophthalmia due to C. trachomatis. Follow-up eye cultures for N. gonorrhoeae were all negative.

• Authors: D A Haase, R A Nash, H Nsanze, L J D'Costa, L Fransen, P Piot, R C Brunham
• Journal: Sexually transmitted diseases (Sex Transm Dis) 1986 Jan-Mar Vol. 13 Issue 1 Pg. 53-5 ISSN: 0148-5717 [Print] United States
• PMID: 3082022 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Ceftriaxone

Topics

• Ceftriaxone (administration & dosage, therapeutic use)
• Cervix Uteri (microbiology)
• Clinical Trials as Topic
• Eye (microbiology)
• Female
• Gonorrhea (drug therapy)
• Humans
• Infant, Newborn
• Injections, Intramuscular
• Neisseria gonorrhoeae (isolation & purification)
• Ophthalmia Neonatorum (drug therapy, microbiology)