Serum Aldosterone as Predictor of Progression of Coronary Heart Disease in Patients Without Signs of Heart Failure After Acute Myocardial Infarction.

Abstract

INTRODUCTION:

In patients with acute myocardial infarction (AMI) early risk assessment of development of complications is of great importance. It is proven that aldosterone level has a major role in progression of cardiovascular pathology.

AIM:

Determination of influence of aldosterone plasma level in the progression of heart disease in patients without signs of heart failure after AMI.

MATERIAL AND METHODS:

Research included 207 patients, hospitalized in the acute phase of myocardial infarction, and who were divided into two groups: 127 patients with no clinical signs of heart failure and 60 patients with heart failure.

RESULTS:

The serum aldosterone concentration was 73.4% higher in the group of decompensated patients, 128 pg/mL (75.4-236 pg/mL) in decompensated and 73.7 pg/mL (42.7 -115.25 pg/mL) in compensated. In the group of compensated patients, changes in aldosterone levels showed a statistically significant effect on the incidence of post-infarction angina (p=0.0001) as well as reinfarction (p=0.009). There is a connection between changes in aldosterone plasma level and positive stress test (p=0.012).

CONCLUSION:

In patients with AMI, elevated serum aldosterone level can be prognostic factor of the progression of coronary heart disease, development of heart failure, as well of development of post-infarction angina, myocardial reinfarction and pathological finding on the stress test.

• Authors: Nerma Resic, Azra Durak-Nalbantic, Alen Dzubur, Alden Begic, Edin Begic
• Journal: Medical archives (Sarajevo, Bosnia and Herzegovina) (Med Arch) Vol. 72 Issue 6 Pg. 406-409 (Dec 2018) ISSN: 1986-5961 [Electronic] Bosnia and Herzegovina
• PMID: 30814770 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Aldosterone

Topics

• Aged
• Aldosterone (blood)
• Biomarkers (blood)
• Coronary Disease (blood, etiology, physiopathology)
• Disease Progression
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Myocardial Infarction (blood, complications, physiopathology)
• Predictive Value of Tests
• Prognosis
• Risk Assessment