Abstract | BACKGROUND: PURPOSES: To examine the efficiency and security of a flexible cryoprobe, we measured the size and temperature distribution of the frozen area ( ice ball) in ex vivo pig lung and liver and the temperature of the bronchoscope. METHODS: We evaluated flexible cryoprobe cryoablation using a bronchoscope in ex vivo pig lung and a flexible cryoprobe alone in ex vivo pig liver. Seven temperature sensors were positioned at the surface of the cryoprobe and at distances of 0.3, 0.6, 0.9, 1.2, 1.5, and 1.8 cm from the cryoprobe. Two temperature sensors were positioned at the surface of the bronchoscope. The ex vivo pig lung and liver were perfused with 37°C saline and the former was inflated using a ventilator to simulate in vivo lung conditions. The whole operation is usually 2-3 freezing cycles. RESULTS: In ex vivo pig liver, probes made ice balls of 33.2 ± 0.2 mm in diameter. In ex vivo pig lung, probes made ice balls of 35.1 ± 1.7 mm in diameter. The temperature at the surface of the bronchoscope at distances of 1 and 10 cm from the cryoprobe reached 21.1 ± 0.1 and 10.5 ± 0.2°C. CONCLUSION: A flexible cryoprobe using a bronchoscope in ex vivo pig lung and liver was a sufficiently safe treatment method.
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Authors | Xiaoxuan Zheng, Chi Yang, Xueyan Zhang, Haibin Yuan, Fangfang Xie, Ying Li, Baikai Xu, Felix J F Herth, Jiayuan Sun |
Journal | Respiration; international review of thoracic diseases
(Respiration)
2019
Vol. 97
Issue 5
Pg. 457-462
ISSN: 1423-0356 [Electronic] Switzerland |
PMID | 30799405
(Publication Type: Journal Article)
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Copyright | © 2019 S. Karger AG, Basel. |
Topics |
- Animals
- Bronchoscopes
- Cryosurgery
(instrumentation, methods)
- Equipment Design
- Liver
(pathology, surgery)
- Lung
(pathology, surgery)
- Lung Neoplasms
(pathology, surgery)
- Swine
- Treatment Outcome
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