Abstract |
Immunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including N. meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits immunized with inactivated pneumococcal cultures, antibodies binding IgA1-protease from N. meningitidis serogroup B were detected. Thus, the cross-reactive protection against meningococcal and pneumococcal infections has been demonstrated in vivo. Presumably it indicates the presence of common epitopes in the N. meningitidis IgA1 protease and S. pneumoniae surface proteins.
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Authors | Olga Kotelnikova, Alexander Alliluev, Alexei Zinchenko, Larisa Zhigis, Yuri Prokopenko, Elena Nokel, Olga Razgulyaeva, Vera Zueva, Marina Tokarskaya, Natalia Yastrebova, Elena Gordeeva, Tatyana Melikhova, Elena Kaliberda, Lev Rumsh |
Journal | Microbes and infection
(Microbes Infect)
2019 Aug - Sep
Vol. 21
Issue 7
Pg. 336-340
ISSN: 1769-714X [Electronic] France |
PMID | 30797878
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Antibodies, Bacterial
- Immune Sera
- Meningococcal Vaccines
- Recombinant Proteins
- Vaccines, Synthetic
- Serine Endopeptidases
- IgA-specific serine endopeptidase
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Topics |
- Animals
- Antibodies, Bacterial
(blood, immunology)
- Cross Protection
- Female
- Immune Sera
(administration & dosage, immunology)
- Meningococcal Infections
(immunology, prevention & control)
- Meningococcal Vaccines
(administration & dosage, immunology)
- Mice, Inbred BALB C
- Neisseria meningitidis
(enzymology, immunology)
- Pneumococcal Infections
(immunology, prevention & control)
- Rabbits
- Recombinant Proteins
(immunology)
- Serine Endopeptidases
(chemistry, immunology)
- Streptococcus pneumoniae
(immunology)
- Vaccines, Synthetic
(administration & dosage, immunology)
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