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Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections.

Abstract
Immunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including N. meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits immunized with inactivated pneumococcal cultures, antibodies binding IgA1-protease from N. meningitidis serogroup B were detected. Thus, the cross-reactive protection against meningococcal and pneumococcal infections has been demonstrated in vivo. Presumably it indicates the presence of common epitopes in the N. meningitidis IgA1 protease and S. pneumoniae surface proteins.
AuthorsOlga Kotelnikova, Alexander Alliluev, Alexei Zinchenko, Larisa Zhigis, Yuri Prokopenko, Elena Nokel, Olga Razgulyaeva, Vera Zueva, Marina Tokarskaya, Natalia Yastrebova, Elena Gordeeva, Tatyana Melikhova, Elena Kaliberda, Lev Rumsh
JournalMicrobes and infection (Microbes Infect) 2019 Aug - Sep Vol. 21 Issue 7 Pg. 336-340 ISSN: 1769-714X [Electronic] France
PMID30797878 (Publication Type: Journal Article)
CopyrightCopyright © 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Chemical References
  • Antibodies, Bacterial
  • Immune Sera
  • Meningococcal Vaccines
  • Recombinant Proteins
  • Vaccines, Synthetic
  • Serine Endopeptidases
  • IgA-specific serine endopeptidase
Topics
  • Animals
  • Antibodies, Bacterial (blood, immunology)
  • Cross Protection
  • Female
  • Immune Sera (administration & dosage, immunology)
  • Meningococcal Infections (immunology, prevention & control)
  • Meningococcal Vaccines (administration & dosage, immunology)
  • Mice, Inbred BALB C
  • Neisseria meningitidis (enzymology, immunology)
  • Pneumococcal Infections (immunology, prevention & control)
  • Rabbits
  • Recombinant Proteins (immunology)
  • Serine Endopeptidases (chemistry, immunology)
  • Streptococcus pneumoniae (immunology)
  • Vaccines, Synthetic (administration & dosage, immunology)

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