Inflammatory bowel disease and bipolar disorder: A population-based cross-sectional study.

Abstract

BACKGROUND:

To date, some experimental studies showed that inflammatory bowel disease (IBD) and bipolar disorder (BD) may share similar biological pathways. Nevertheless, only a few western studies have attempted to demonstrate the potential association between IBD and BD, and relevant findings are still conflicting. Therefore, this cross-sectional study aimed to evaluate the relationship between IBD and BD using a nationwide database in Taiwan.

METHOD:

This study used data from the National Health Insurance Research Database. In total, 3590 patients with IBD and 14,360 propensity score-matched comparison patients without IBD were included in this study. Conditional logistic regressions were performed to evaluate the association between BD and IBD.

RESULTS:

Results showed that BD was found in 26 (0.72%) patients with IBD and in 49 (0.34%) matched comparison patients without IBD. After adjustment, the adjusted odds ratio (OR) of BD for IBD patients was 2.10 (95% confidence interval (CI): 1.30∼3.38) compared to the comparison group. Additionally, this study showed that adjusted OR of BD for ulcerative colitis patients were 2.23 (95% CI: 1.31∼3.82) compared to the comparison group.

LIMITATIONS:

we could not precisely determine the causal association between BD and IBD.

CONCLUSIONS:

We concluded that patients with IBD were more likely to have BD than those comparison patients without IBD.

• Authors: Li-Ting Kao, Herng-Ching Lin, Hsin-Chien Lee
• Journal: Journal of affective disorders (J Affect Disord) Vol. 247 Pg. 120-124 (Mar 15 2019) ISSN: 1573-2517 [Electronic] Netherlands
• PMID: 30660021 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019. Published by Elsevier B.V.

Topics

• Adult
• Bipolar Disorder (complications, epidemiology)
• Colitis, Ulcerative (epidemiology, psychology)
• Crohn Disease (epidemiology, psychology)
• Cross-Sectional Studies
• Databases, Factual
• Female
• Humans
• Inflammatory Bowel Diseases (epidemiology, psychology)
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Risk Factors
• Taiwan (epidemiology)