Six versus eight doses of rituximab in patients with aggressive B cell lymphoma receiving six cycles of CHOP: results from the "Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas" (PETAL) trial.
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| Abstract |
Standard first-line treatment of aggressive B cell lymphoma comprises six or eight cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus eight doses of rituximab (R). Whether adding two doses of rituximab to six cycles of R-CHOP is of therapeutic benefit has not been systematically investigated. The Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL) trial investigated the ability of [18F]-fluorodesoxyglucose PET scanning to guide treatment in aggressive non-Hodgkin lymphomas. Patients with B cell lymphomas and a negative interim scan received six cycles of R-CHOP with or without two extra doses of rituximab. For reasons related to trial design, only about a third underwent randomization between the two options. Combining randomized and non-randomized patients enabled subgroup analyses for diffuse large B cell lymphoma (DLBCL; n = 544), primary mediastinal B cell lymphoma (PMBCL; n = 37), and follicular lymphoma (FL) grade 3 (n = 35). With a median follow-up of 52 months, increasing the number of rituximab administrations failed to improve outcome. A non-significant trend for improved event-free survival was seen in DLBCL high-risk patients, as defined by the International Prognostic Index, while inferior survival was observed in female patients below the age of 60 years. Long-term outcome in PMBCL was excellent. Differences between FL grade 3a and FL grade 3b were not apparent. The results were confirmed in a Cox proportional hazard regression model and a propensity score matching analysis. In conclusion, adding two doses of rituximab to six cycles of R-CHOP did not improve outcome in patients with aggressive B cell lymphomas and a fast metabolic treatment response.
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| Authors | Andreas Hüttmann, Jan Rekowski, Stefan P Müller, Bernd Hertenstein, Christiane Franzius, Rolf Mesters, Matthias Weckesser, Frank Kroschinsky, Jörg Kotzerke, Arnold Ganser, Frank M Bengel, Paul La Rosée, Martin Freesmeyer, Heinz-Gert Höffkes, Andreas Hertel, Dirk Behringer, Gabriele Prange-Krex, Martin Griesshammer, Jens Holzinger, Stefan Wilop, Thomas Krohn, Aruna Raghavachar, Georg Maschmeyer, Ingo Brink, Roland Schroers, Tobias Gaska, Helga Bernhard, Aristoteles Giagounidis, Jochen Schütte, Ariane Dienst, Hubertus Hautzel, Ralph Naumann, Alfred Klein, Dennis Hahn, Gabriele Pöpperl, Matthias Grube, Jörg Marienhagen, Andreas Schwarzer, Lars Kurch, Thomas Höhler, Heike Steiniger, Holger Nückel, Thomas Südhoff, Wolfgang Römer, Marcus Brinkmann, Claudia Ose, Ferras Alashkar, Christine Schmitz, Jan Dürig, Dieter Hoelzer, Karl-Heinz Jöckel, Wolfram Klapper, Ulrich Dührsen |
| Journal | Annals of hematology (Ann Hematol) Vol. 98 Issue 4 Pg. 897-907 (Apr 2019) ISSN: 1432-0584 [Electronic] Germany |
| PMID | 30610279 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial) |
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