[Medicaments and oral healthcare. Systematic review of the -literature assessing the effect of drugs on the salivary glands].

Abstract

Evidence-based reviews of drugs causing medication-induced salivary gland dysfunction, such as xerostomia (sensation of oral dryness) and subjective sialorrhea are lacking. To compile a list of medicaments that influence salivary gland function, electronic databases were searched for relevant articles published up to June 2013. A total of 269 papers out of 3,867 records located satisfied the inclusion criteria (relevance, quality of methodology, strength of evidence). A total of 56 active substances with a higher level of evidence and 50 active substances with a moderate level of evidence of causing salivary gland dysfunction are described in this article. While xerostomia was a commonly reported outcome, the objective effect on salivary secretion was rarely measured. Xerostomia was, moreover, mostly reported as a negative side effect instead of the intended effect of that drug. A comprehensive list of medications having documented effects on salivary gland function or symptoms was compiled, which may assist practitioners in assessing patients who complain of dry mouth while taking medications.

• Authors: A Wolff, R K Joshi, J Ekström, D Aframian, A M L Pedersen, G Proctor, N Narayana, A Villa, Y W Sia, A Aliko, R McGowan, R Kerr, S B Jensen, A Vissink, C Dawes
• Journal: Nederlands tijdschrift voor tandheelkunde (Ned Tijdschr Tandheelkd) Vol. 125 Issue 11 Pg. 593-601 (11 2018) ISSN: 0028-2200 [Print] Netherlands
• Vernacular Title: Serie: Medicamenten en mondzorg.Systematisch literatuuronderzoek naar effect van medicatie op de speekselklieren.
• PMID: 30457580 (Publication Type: Journal Article, Systematic Review)

Topics

• Humans
• Salivary Glands (drug effects)
• Xerostomia (etiology)