Cross-Reactive Flavivirus Antibody: Friend and Foe?

Abstract

The introduction of Zika virus (ZIKV) into the Americas sparked interest in the influence of heterologous antibodies on sequential ZIKV and dengue virus (DENV) infections. In this issue of Cell Host & Microbe, Fowler et al. (2018) demonstrate in mice that maternally acquired anti-ZIKV antibodies exacerbate disease following DENV challenge.

• Authors: Sonia Maciejewski, Theodore C Pierson
• Journal: Cell host & microbe (Cell Host Microbe) Vol. 24 Issue 5 Pg. 622-624 (11 14 2018) ISSN: 1934-6069 [Electronic] United States
• PMID: 30439339 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
• Copyright: Copyright © 2018. Published by Elsevier Inc.

Chemical References

• Antibodies, Monoclonal
• Antibodies, Neutralizing
• Antibodies, Viral
• Viral Proteins

Topics

• Animals
• Antibodies, Monoclonal (immunology)
• Antibodies, Neutralizing (immunology)
• Antibodies, Viral (immunology)
• Cross Reactions (immunology)
• Dengue (immunology, virology)
• Dengue Virus (immunology, pathogenicity)
• Flavivirus (immunology)
• Flavivirus Infections (immunology, virology)
• Immunity
• Mice
• Viral Proteins (immunology)
• Zika Virus (immunology, pathogenicity)
• Zika Virus Infection (immunology, virology)