Highly Cancer Selective Antiproliferative Activity of Natural Prenylated Flavonoids.

Abstract

Xanthohumol (XN) and four minor hops prenylflavonoids: α,β-dihydroxanthohumol (2HXN), isoxanthohumol (IXN), 8-prenylnaringenin (8PN), and 6-prenylnaringenin (6PN), were tested for antiproliferative activity towards human cancer and normal cell lines. Nonprenylated naringenin (NG) was used as a model compound. Xanthohumol, α,β-dihydroxanthohumol and 6-prenylnaringenin were the most active compounds. Xanthohumol exhibited higher antiproliferative activity than cisplatin (CP) against five cancer cell lines: ovarian resistant to cisplatin A2780cis, breast MDA-MB-231 and T-47D, prostate PC-3, and colon HT-29. Isoxanthohumol was more potent than cisplatin against breast cancer cell lines MDA-MB-231 and T-47D whereas 6-prenylnaringenin was stronger than cisplatin against breast cancer cell line T-47D. It was found that tested chalcones possessed highly selective antiproliferative activity towards all tested breast cancer lines compared to the normal breast MCF 10A cell line (the calculated selectivity index ranged from 5 to 10). Low antiproliferative activity of naringenin indicates the importance of the prenyl group with respect to antiproliferative activity.

• Authors: Agnieszka Bartmańska, Tomasz Tronina, Jarosław Popłoński, Magdalena Milczarek, Beata Filip-Psurska, Joanna Wietrzyk
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 23 Issue 11 (Nov 09 2018) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 30423918 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Biological Products
• Flavonoids
• Propiophenones
• xanthohumol

Topics

• Antineoplastic Agents (chemistry, pharmacology)
• Biological Products (chemistry, pharmacology)
• Cell Line, Tumor
• Flavonoids (chemistry, pharmacology)
• Humans
• Inhibitory Concentration 50
• MCF-7 Cells
• Magnetic Resonance Spectroscopy
• Molecular Structure
• Prenylation
• Propiophenones (chemistry)