[A Case of Sister Mary Joseph's Nodule from Transverse Colon Cancer Effectively Treated with SOX plus Bevacizumab Chemotherapy].

Abstract

A 47-year-old woman presented with a hard umbilical nodule that appeared red and was painful. A biopsy of the umbilical nodule revealed adenocarcinoma. As a result of general examinations, the patient was diagnosed with umbilical, hepatic, and ovarian metastases from transverse colon cancer. She was treated with S-1 and oxaliplatin(SOX)plus bevacizumab chemotherapy. After 4 courses of chemotherapy, CT revealed that the primary lesion and umbilical and hepatic metastases had reduced in size. We considered this to be a partial response and thus administered 4 additional courses of SOX plus bevacizumab chemotherapy. Finally, she remained well for 22 months and achieved relatively good prognosis. An umbilical metastasis from an internal malignancy is known as a Sister Mary Joseph's nodule, and it has very poor prognosis. Most studies show that the survival period from the time of diagnosis is within 1 year. However, our case suggests that novel anti-cancer drugs or molecular-targeted agents may improve survival.

• Authors: Chihoko Nobori, Yasutake Uchima, Naoki Aomatsu, Takuma Okada, Hironari Miyamoto, Shigeaki Kurihara, En Wang, Toshiki Hirakawa, Takehiko Iwauchi, Junya Morimoto, Shigehito Yamagata, Kazunori Nakazawa, Kazuhiro Takeuchi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 45 Issue 10 Pg. 1457-1459 (Oct 2018) ISSN: 0385-0684 [Print] Japan
• PMID: 30382045 (Publication Type: Case Reports, Journal Article)

Chemical References

• Drug Combinations
• Oxaliplatin
• S 1 (combination)
• Tegafur
• Bevacizumab
• Oxonic Acid

Topics

• Adenocarcinoma (drug therapy, secondary)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bevacizumab (administration & dosage)
• Colon, Transverse (pathology)
• Colonic Neoplasms (drug therapy, pathology)
• Drug Combinations
• Female
• Humans
• Middle Aged
• Oxaliplatin (administration & dosage)
• Oxonic Acid (administration & dosage)
• Sister Mary Joseph's Nodule (drug therapy, secondary)
• Tegafur (administration & dosage)